Cell cycle-dependent glucocorticoid receptor phosphorylation and activity.
نویسندگان
چکیده
منابع مشابه
Cell Cycle Phase Regulates Glucocorticoid Receptor Function
The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. In contrast to many other nuclear receptors, GR is thought to be exclusively cytoplasmic in quiescent cells, and only translocate to the nucleus on ligand binding. We now demonstrate significant nuclear GR in the absence of ligand, which requires nuclear localisati...
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This paper summarizes our observations on the phosphorylation state of untransformed and transformed glucocorticoid receptors isolated from 32P-labeled L-cells. The 300-350-kDa 9S untransformed murine glucocorticoid receptor complex is composed of a 100-kDa steroid-binding phosphoprotein and one or possibly two units of the 90-kDa heat shock protein (hsp90), which is also a phosphoprotein. Tran...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1994
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.8.12.7708059